Alpha-lipoic acid

Alpha-lipoic acid is an antioxidant found in many foods. Antioxidants are substances that the body can use to prevent or manage a tissue-damaging process (oxidative stress). Oxidative stress is a part of the diabetic neuropathy disease process. Alpha-lipoic acid also has been shown to lower blood sugar levels.

In a few small studies, people who had diabetic neuropathy experienced less pain, improved performance on nerve function tests, and improvements in other signs and symptoms. Larger studies are needed.

Alpha-lipoic acid supplements are generally considered safe when taken as recommended. However, if you take this supplement when you have a significant thiamin (vitamin B-1) deficiency, alpha-lipoic toxicity might occur. Don't use alpha-lipoic acid if you're a heavy alcohol user.

Natural sources of alpha-lipoic acid include spinach, broccoli and yeast.